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USANA In-House Clinical Research Posters

• Hepasil DTX™ Increases Antioxidant and Detoxification Capacity by Boosting Glutathione and Vitamin C (2)
• Advanced Doses of Vitamin D are Required to Achieve Optimal Vitamin D Status, Particularly During the Winter
• Bioavailability of Epicatechin after Consumption of Grape Seed Extract in Humans
• Bioavailability of USANA Essentials vs Four Select Competitor Products
  
• Grape Seed Extract Plus Vitamin C Improves Indices of Vascular Health
• Hepasil DTX™ Increases Antioxidant and Detoxification Capacity by Boosting Glutathione and Vitamin C (1)
  
• Method of Assessment of Antioxidant Status In Vivo
• Vitamin D Supplementation is Required During the Winter to Obtain Optimal Vitamin D Status
  

USANA In-House Clinical Research Papers

• Effects of Antioxidant Supplementation on Oxidative Stress in Trained Cyclists
• Glycemic Index (GI) Score for USANA's Peanut Butter Crunch Nutrition Bar
• Pharmacokinetics of Poly C versus Ascorbic Acid
• Bioavailability of Silicon from Three Sources
• Comparative Bioavailability of Coenzyme Q10 in Four Formulations
• Effects of Broad-Spectrum Antioxidant Supplementation on the Antioxidant Status of Human Plasma
• Glycemic Index (GI) Score for USANA's Fibergy Bar and Chocolate Nutrimeal
• Calcium-Magnesium-Vitamin D Supplementation Improves Bone Mineralization in Preadolescent Girls
• Glycemic Index (GI) Scores for USANA's Chocolate, Vanilla, and Strawberry Nutrimeals
• Glycemic Index (GI) Score for USANA's Oatmeal Raisin Nutrition Bar
• Glycemic Index (GI) Score for USANA's TenX Antioxidant Blast Dietary Supplement
• A Novel Assay for Determining Plasma Antioxidant Capacity
• Comparative Absorption of Water Soluble Vitamins from Five Supplements
• Ubiquinone versus Ubiquinol Clinical Research Bulletin

USANA Patents

• Cuomo, J., Brown, M.J., Dixon, B.M., Dern, A.S. Methods for Using Nutritional Supplements Containing Lipoic Acids and Sulfur Containing Compounds. Patent Pending. Filed August, 2011. #13/213,313.
• Cuomo, J., Brown, M.J., Dixon, B.M., Schneider, E. Nutritional Supplements Containing Lipoic Acids and Sulfur Containing Compounds. Patent Pending. Filed August, 2011. #13/196,390.
• McDonald JH, McDonald SC, Lundmark LD, Kabara JJ, Garruto JA, USANA Health Sciences, Inc. 2007. U.S. Patent No 7,214,391. Salt Lake City, UT: U.S. Patent and Trademark Office.
• Cuomo J, Rabovsky AB, USANA Health Sciences, Inc. 2002. U.S. Patent No 6,361,803. Salt Lake City, UT: U.S. Patent and Trademark Office.
• Cuomo J, Rabovsky AB, USANA Health Sciences, Inc. 2002. U.S. Patent No 6,358,542. Salt Lake City, UT: U.S. Patent and Trademark Office.

Other USANA In-House Research

• Cuomo J, Appendino G, Dern AS, Schneider E, McKinnon TP, Brown MJ, Togni S, Dixon BM. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. 2011. J Nat Prod 74(4):664-9.
• Eich N, Schneider E, Cuomo J, Rabovsky A, Vita JA, Palmisano J, Holbrook M. Bioavailability of epicatechin after consumption of grape seed extract in humans. 2007. FASEB 21:lb289.
• Rabovsky A, Cuomo J, Eich N. Measurement of plasma antioxidant reserve after supplementation with various antioxidants in healthy subjects. 2006. Clinica Chimica Acta 371(1-2):55-60.
• Preobrazhensky S, Malugin A, Wentz M. Flow cytometric assay for evaluation of the effects of cell density on cytotoxicity and induction of apoptosis. 2001. Cytometry 43(3):199-203.
• Gamache P, Rabovsky A, Cuomo J. Lipoic acid analysis in food supplements by HPLC with Coulometric Array Detector. 1999. Presentation, Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, Pittsburgh, Pennsylvania, USA.
• Rabovsky A, Cuomo J. Olive oil: Direct measure of antioxidant activity. 1999. Free Rad Bio Med 27(Supp 1):S42.
• Rabovsky A, Cuomo J, Wentz M. Inhibition of fat absorption with grape seed antioxidants. 1998. Free Rad Bio Med 25(Supp 1):96.
• McDonald J, Preobrazhensky S, Malugin A, Rabovsky A, Wood T, Wentz M. Effect of Vitamin E Supplementation on susceptibility to oxidation of isolated low density lipoprotein and apolipoprotein B-100 in unfractionated blood. 1997. Abstract Presentation, XI International Symposium on Atherosclerosis, Paris, France.
• Preobrazhensky S, Rabovsky A, Goldmacher V, Wentz M. Comparative study of cytotoxic action of low density lipoprotein and cumene hydroperoxide on various lymphoid cell lines. 1997. XI International Symposium on Atherosclerosis, Paris, France.
• Ivanov V, Rabovsky A. Extracellular Matrix Regulates Proliferation Rate of Vascular Smooth Muscle Cells: Role of Hyaluronic acid. 1996. Abstract Presentation, Becton Dickinson Symposium on Extracellular Matrix, ECM Interactions, London, UK.
• Rabovsky A, Preobrazhensky S, Wentz M. In vitro antioxidant activity of flavonoids measured using different procedures. 1996. Abstract Presentation, 3rd Annual Meeting of the Oxygen Society, Miami Beach, Florida, USA.
• Rabovsky A, Preobrazhensky S, Wentz M. Protection of cultured human cells from oxidative damage by alpha-tocopherol, ascorbic acid and flavonoids. 1996. Abstract Presentation, VIII Biennial Meeting International Society for Free Radical Research, Barcelona, Spain.
• Rabovsky A, Preobrazhensky S, Wentz M. Synergistic action of Ascorbic Acid and Bioflavonoids in protecting Apolipoprotein B from oxidation. 1996. Abstract Presentation, VIII Biennial Meeting International Society for Free Radical Research, Barcelona, Spain.
• Preobrazhensky S, Trakht I, Chestkov V, Wentz M. Monoclonal antibody-based immunoassay for evaluation of lipoprotein oxidation. 1995. Analytical Biochemistry 227(1):225-34.
• Mazumder P, Chuang HY, Wentz MW, Wiedbrauk DL. Latex agglutination test for detection of antibodies to Toxoplasma gondii. 1988. J Clin Microbiol 26(11):2444-6.

Third-Party Research Performed in Collaboration with USANA

• Ball SD, Keller KR, Moyer-Mileur LJ, Ding YW, Donaldson D, Jackson WD. Prolongation of satiety after low versus moderately high glycemic index meals in obese adolescents. 2003. Pediatrics 111:488-94.
• Barker T, Henriksen VT, Martins TB, et al. Higher serum 25-hydroxyvitamin d concentrations associate with a faster recovery of skeletal muscle strength after muscular injury. Nutrients. 2013;5(4):1253-75.
• Barker T, Leonard SW, Hansen J, Trawick RH, Ingram R, Burdett G, Lebold K, Walker JA, Traber MG. Vitamin E and C supplementation does not ameliorate muscle dysfunction following anterior cruciate ligament surgery. 2009. Free Radic Biol Med 47:1611-8.
• Barker T, Leonard SW, Martins TB, Trawick RH, Hill HR, Kjeldsberg CR, Traber MG. Cytokine alteration following antioxidant supplementation and anterior cruciate ligament surgery. 2009. American College of Sports Medicine Annual Meeting, Seattle, Washington.
• Barker T, Leonard S, Trawick RH, Martins TB, Hill HR, Traber MG. The influence of alpha-tocopherol and ascorbic acid on circulating inflammatory cytokines following anterior cruciate ligament surgery. 2008. Free Radical Summer School, Spetses, Greece.
• Barker T, Leonard SW, Trawick RH, Martins TB, Kjeldsberg CR, Hill HR, Traber MG. Modulation of inflammation by vitamin E and C supplementation prior to anterior cruciate ligament surgery. 2009. Free Radic Biol Med 46:599-606.
• Barker T, Leonard SW, Trawick RH, Martins TB, Kjeldsberg CR, Hill HR, Walker JA, Traber MG. The supplementation of vitamins E and C modulate the relationship between circulating mediators of muscle weakness but not limb strength following anterior cruciate ligament surgery. 2009. Diet and Optimum Health Conference, Portland, OR.
  
• Barker T, Leonard SW, Trawick RH, Walker JA, Traber MG. Antioxidant supplementation lowers circulating IGF-1 but not F2-isoprostanes immediately following ACL surgery. 2009. Redox Report 14:221-6.
• Barker T, Martins TB, Hill HR, Kjeldsberg CR, Trawick RH, Leonard SW, Walker JA, Traber MG. Antioxidants induced cytokine alterations indicative of a better prognosis after ACL surgery. 2010. Experimental Biology, Anaheim, CA.
  
• Barker T, Martins TB, Hill HR, Kjeldsberg CR, Trawick RH, Leonard SW, Walker JA, Traber MG. Vitamin E and C supplementation modulates cytokine associations after ACL surgery indicative of a better prognosis. 20XX. International Journal of Sport Nutrition and Exercise Metabolism, under review.
• Barker T, Martins TB, Hill HR, Kjeldsberg CR, Trawick RH, Leonard SW, Walker JA, Traber MG. (2011) Vitamins E and C modulate the association between reciprocally regulated cytokines after an anterior cruciate ligament injury and surgery. Am J Phys Med Rehabil 90:638-647.
• Barker T, Traber MG. Does Vitamin E and C Supplementation Improve the Recovery from Anterior Cruciate Ligament Surgery?. 20XX. Journal of Evidence-Based Complementary & Alternative Medicine, in review.
  
• Bemer B, Krueger SK, Orner GA. Sulindac pharmacokinetics. The role of flavin-containing monooxygenases. 2008. Howard Hughes Medical Institute, Summer Internship Presentation, Oregon State University, September 26.
• Bosse JD, Dixon BM. Dietary protein in weight management: a review proposing protein spread and change theories. Nutr Metab (Lond). 2012;9(1):81.
• Bosse JD, Dixon BM. Dietary protein to maximize resistance training: a review and examination of protein spread and change theories. J Int Soc Sports Nutr. 2012;9(1):42.
• Dixon BM, Barker T, McKinnon T, Cuomo J, Frei B, Borregaard N, Gombart A. Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in health adults. BMC Research Notes. 2012;5:575.
• Edwards RL, Lyon T, Litwin Se, Rabovsky A, Symons JD, Jalili T. . 2007. J Nutr 137:2405-11.
• Frei, B., Birlouez-Aragon, I., and Lykkesfeldt, J. (2012) Authors’ perspective: What is the optimum intake of vitamin C in humans? Crit. Rev. Food Sci. Nutr. 52(9):815-29.
• Greene DA, Naughton GA. Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial. 2010. Osteoporosis International, in review.
• Johnson S, Hagen TM. Changes in Acute Human Plasma Glutathione Levels Following Lipoic Acid Supplementation. 2009. Howard Hughes Medical Institute Summer Internship presentation, Oregon State University, September 24, 2009, and Center for Health Aging Research Life Scholars presentation, Oregon State University, October 14, 2009.
  
• Jubert C, Mata J, Bench G, Dashwood R, Pereira C, Tracewell W, Turteltaub K, Williams D, Baily G. Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B1 pharmacokinetics in human volunteers. 2009. Cancer Prevention Research 2(12):1015-22.
• Kesinger NG, Langsdorf BL, Yokochi AF, Miranda CL, and Stevens JF. Formation of a vitamin C conjugate of acrolein and its paraoxonase-mediated conversion into 5,6,7,8-tetrahydroxy-4-oxooctanal. 2010. Chem Res Toxicol 23:836-44.
• Leonard SW, Barker T, Mustacich DJ, Traber MG. Measurement of vitamin K homologues in biological fluids and tissues by APCI LC/MS. 2009. Diet and Optimum Health Conference, Portland, OR.
• Leonard SW, Barker T, Mustacich DJ, Traber MG. Measurement of vitamin K homologues in biological fluids and tissues by APCI LC/MS. 2010. Experimental Biology, Anaheim, CA.
  
• Leonard SW, Barker T, Taylor AW, Traber MG. APCI LC-MS quantitation of vitamin K in the plasma of anterior cruciate ligament surgery patients. 20XX. Analytical Biochemistry, in review.
• Lotito SB, Zhang WJ, Yang CS, Crozier A, and Frei B. (2011) Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties. Free Radic Biol Med 51:454-463.
• Michels AJ, Dickinson BC, Chang CJ, Frei B. Generation of H₂O₂ by ascorbate auto-oxidation: possible implications for cancer therapy. 2010. Society for Free Radical Biology and Medicine Annual Meeting, Orlando, FL.
• Moyer-Mileur LJ, Xie B, Ball SD, Pratt T. Bone mass and density response to a 12-month trial of calcium and vitamin D supplement in preadolescent girls. 2003. J Musculoskel Neuron Interact 3(1):63-70.
• Peluso MR, Miranda CL, Hobbs DJ, Proteau RR, Stevens JF. Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2). 2010. Planta Med 76:1536-43.
• Shenouda SM, Hamburg NM, Holbrook M, Chung W, Caiano T, Duess MA, Kluge M, Chernyshev V, Tabit C, McKinnon T, Wood T, Cuomo J, Dixon B, Eich N, Vita JA. Chronic Study of the Effect of Grape Seed Extract plus Ascorbic Acid on Endothelial Function in Patients with Coronary Artery Disease p. 104. 2010. Nutrition, Physical Activity and Metabolism Conference, and 50th Cardiovascular Disease Epidemiology and Prevention Annual Conference, San Francisco, CA, USA.
  
• Song Y, Chung CS, Bruno RS, Traber MG, Brown KH, King JC, Ho E. Dietary zinc restriction and repletion affects DNA integrity in healthy men. 2009. Am J Clin Nutr 90:321-8.
• Song Y, Chung CS, Bruno RS, Traber MG, Brown KH, King JC, Ho E. Zinc status affects DNA damage and oxidative stress in healthy adult men. 2009. FASEB J 23:216.1. (Yang Song won the Young Investigator award with the American Society of Nutrition for this work.)
  
• Song Y, Ho E. Effects of zinc deficiency on DNA damage, oxidative stress and oxidant defense in peripheral blood. 2008. FASEB J 22:A697.
• Traber MG, Barker T. Vitamins E and C in ACL (Anterior Cruciate Ligament) Injury. 2009. 3rd International Symposium; Nutrition, Oxygen Biology and Medicine. Paris, France.
• Wolinsky LE, Cuomo J, Quesada K, Bato T, Camargo PM. A comparative pilot study of the effects of a dentifrice containing green tea bioflavonoids, sanguinarine or triclosan on oral bacterial biofilm formation. 2000. J Clin Dent 11(2):53-9.
• Wyatt HR, Ogden LG, Cassic KS, Hoagland EA, McKinnon T, Eich N, Chernyshev V, Wood T, Cuomo J, Hill JO. Successful internet-based lifestyle change program on body weight and markers of metabolic health. 2009. Obesity and Weight Management 5(4):167-73.
• Yilmazer-Musa M, Griffith AM, Michels AJ, Schneider E, Frei B. (2012) Grape seed extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity. J Agric Food Chem. 2012 Jun 29.
• Yilmazer-Musa M, Tucker AM, Frei B. Inhibition of a-amylase and a-glucosidase activity by bioflavonoids: implications for carbohydrate metabolism and type-2 diabetes mellitus. 2010. Society for Free Radical Biology and Medicine Annual Meeting, Orlando, FL.